New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

New Ligands for Nickel Catalysis from Diverse Pharmaceutical Heterocycle Libraries

Ligands are essential for controlling the reactivity and selectivity of reactions catalysed by transition metals. Access to large phosphine ligand libraries has become an essential tool for the application of metal-catalysed reactions industrially, but these existing libraries are not well suited to new catalytic methods based on non-precious metals (for example, Ni, Cu and Fe). The development...

A Universal Isocyanide for Diverse Heterocycle Syntheses

Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

A combinatorial scaffold approach toward kinase-directed heterocycle libraries.

A novel strategy for efficient synthesis of various substituted heterocycles as kinase-directed combinatorial libraries is described. The general scheme involves capture of various dichloroheterocycles onto solid support and further elaborations by aromatic substitution with amines at elevated temperature or by anilines, boronic acids, and phenols via palladium-catalyzed cross-coupling reaction...

Chiral olefin ligands-new "spectators" in asymmetric catalysis.

New Applications of Tridentate Bis(oxazoline) Ligands in Asymmetric Catalysis

Finding interactions between microRNAs and their mRNA targets is a challenging experimental and computational problem. While several novel experimental high throughput approaches have been developed for measuring miRNA expression, the amount of data generated from these technologies is dwarfed by the amount of data existing in current gene expression microarray repositories. Many microRNAs over...